A little like the difference in a Les Paul and a 335. My Studios have a more immediate response and a little punchier sound, where the Artist 25th Anniversary I have is fat and warm sounding even though they have the same pickups. of course that could be more due to the fact that it is all mahogany. I had an Artist Custom with Seth lovers in it a long time ago. It was a great guitar, and I should have kept it, it sounded brighter than my current Artist, but not as punchy as my Studios. They all have their own personality, and you can't go wrong with any of them.